It has long been recognized that cancer onset and progression represent a type of reversion to an ancestral quasi‐unicellular phenotype. This general concept has been refined into the atavistic model of cancer that attempts to provide a quantitative analysis and testable predictions based on genomic data. Over the past decade, support for the multicellular‐to‐unicellular reversion predicted by the atavism model has come from phylostratigraphy. Here, we propose that cancer onset and progression involve more than a one‐off multicellular‐to‐unicellular reversion, and are (...) better described as a series of reversionary transitions. We make new predictions based on the chronology of the unicellular‐eukaryote‐to‐multicellular‐eukaryote transition. We also make new predictions based on three other evolutionary transitions that occurred in our lineage: eukaryogenesis, oxidative phosphorylation and the transition to adaptive immunity. We propose several modifications to current phylostratigraphy to improve age resolution to test these predictions. Also see the video abstract here: https://youtu.be/3unEu5JYJrQ. (shrink)

Little is known about how ethical organizational contexts influence employees’ perceived stress levels and well-being. This study used two theoretical lenses, ethical impact theory (Promislo et al. in Handbook of Unethical Work Behavior, M.E. Sharpe, Armonk, 2013) and ethical decision-making theory (Schwartz in J Bus Ethics 139(4): 755–776, 2016), to investigate the relationships among perceived organizational ethics (comprised of ethical climate, leader/manager ethics, and corporate social responsibility), work-related stress, and employee well-being (comprised of vitality, life satisfaction, personal growth initiative, flourishing, (...) positive mental health, and self-actualization). Findings across two studies indicated that organizational ethics was negatively related to work-related stress, and that work-related stress was negatively related to employee well-being. Perceived organizational ethics is positively related to employee well-being, with post hoc mediation tests indicating that work-related stress partially mediates this relationship. Our findings suggest that organizations should be proactive in improving their ethical climate, such as choosing ethical leaders, developing a robust and well-communicated code of ethics, and actively practicing CSR. These measures should reduce excessive work-related stress and improve employee well-being. (shrink)

Philosophers of science often make reference — whether tacitly or explicitly — to the notion of a scientific community. Sometimes, such references are useful to make our object of analysis tractable in the philosophy of science. For others, tracking or understanding particular features of the development of science proves to be tied to notions of a scientific community either as a target of theoretical or social intervention. We argue that the structure of contemporary scientific research poses two unappreciated, or at (...) least underappreciated, challenges to this concept of the “scientific community” in the philosophy of science. In particular, we will present two case studies from robotics research, broadly construed, which show that (1) the boundedness of the scientific community is threatened when private citizens can develop scientific and technological advances at minimal expense (democratization), and (2) the discreteness of scientific research programs is threatened by the complexly interrelated environment of contemporary scientific work (interconnectivity). Taken together, the extent of democratization and interconnectivity present a significant challenge for any practically oriented philosophy of science, one which we hope will be taken on directly by philosophers in the future. (shrink)

The book shares Žižek's central problem of how to revitalize the radical political left through theory. It initially follows the argument developed in The Ticklish Subject that contemporary leftist thought is divided by antagonism between a Marxist revolutionary politics founded on Enlightenment philosophy and a politics of identity founded on post-modern post-structuralism. How Žižek used Lacan's theory of character structures is examined here to describe this theoretical deadlock and explain how the dominant contemporary ideologies of liberal tolerant multiculturalism and reactionary (...) "pseudo-fundamentalism" compete to mobilize the individual subject's unconscious drive to enjoyment. The book thus emphasizes the moments in which Žižek hints that Lacanian theory may describe a practice that facilitates the resolution of antagonisms that placate radical leftist politics. It challenges prevalent interpretations of Lacanian ends of analysis, to ultimately connect the psychoanalytic cure to the leftist project of social and political liberation. The Subject of Liberation argues that if Lacan is to be useful to leftist politics, then the left has to develop its own definitions of the post-analytic subject, and proposes one such definition developed out of Lacanian and Zizekian theory. (shrink)

Philosophy of science is expanding via the introduction of new digital data and tools for their analysis. The data comprise digitized published books and journal articles, as well as heretofore unpublished material such as images, archival text, notebooks, meeting notes, and programs. The growth in available data is matched by the extensive development of automated analysis tools. The variety of data sources and tools can be overwhelming. In this article, we survey the state of digital work in the philosophy of (...) science, showing what kinds of questions can be answered and how one can go about answering them. (shrink)

Recent arguments concerning the nature of causation in evolutionary theory, now often known as the debate between the 'causalist' and 'statisticalist' positions, have involved answers to a variety of independent questions – definitions of key evolutionary concepts like natural selection, fitness, and genetic drift; causation in multi-level systems; or the nature of evolutionary explanations, among others. This Element offers a way to disentangle one set of these questions surrounding the causal structure of natural selection. Doing so allows us to clearly (...) reconstruct the approach that some of these major competing interpretations of evolutionary theory have to this causal structure, highlighting particular features of philosophical interest within each. Further, those features concern problems not exclusive to the philosophy of biology. Connections between them and, in two case studies, contemporary metaphysics and philosophy of physics demonstrate the potential value of broader collaboration in the understanding of evolution. (shrink)

Through criticism and analysis of ancient traditions, Kahn reconstructs the pattern of Anaximander’s thought using historical methods akin to the reconstructive techniques of comparative linguists.

The Rise of Chance in Evolutionary Theory: A Pompous Parade of Arithmetic explores a pivotal conceptual moment in the history of evolutionary theory: the development of its extensive reliance on a wide array of concepts of chance. It tells the history of a methodological and conceptual development that reshaped our approach to natural selection over a century, ranging from Darwin’s earliest notebooks in the 1830s to the early years of the Modern Synthesis in the 1930s. Far from being a “pompous (...) parade of arithmetic,” as one early critic argued, evolution transformed during this period to make these conceptual and technical tools indispensable. This book charts the role of chance in evolutionary theory from its beginnings to the earliest days of modern evolutionary theory, making it an ideal resource for evolutionary biologists, historians, philosophers, and researchers in science studies or biological statistics. (shrink)

Charles Darwin (1809–1882) Charles Darwin is primarily known as the architect of the theory of evolution by natural selection. With the publication of On the Origin of Species in 1859, he advanced a view of the development of life on earth that profoundly shaped nearly all biological and much philosophical thought which followed. A number….

This volume presents a series of essays published by Charles Kahn over a period of forty years, in which he seeks to explicate the ancient Greek concept of ...

What is new in Ch. H. Kahn reinterpretation of Plato's "Cratylus" is the way he considers its main problem: the question of correctness of names. In traditional approach there are two opposite theses: 1) names are conventional; 2) names are regarded as natural. Kahn, however, maintains that Plato is in fact concerned with a quite different pair of questions. The first one is the sign relation of the language and its role in the communication. The other is the sense and (...) the role of the study of names as a means for investigating the nature of things. (shrink)

For many years, researchers and practitioners have sought out meaningful indicators of sales performance. Yet, as the concept of performance has broadened, the understanding of what makes up a successful seller, has become far more complicated. The complexity of buyer–seller relationships has changed therefore as the definition of sales performance has expanded, cultivating a growing interest in ethical/unethical actions since they could potentially have impacts on sales performance. Given this environment, the purpose of this study is to explore the impact (...) of moral judgment on sales performance and sellers engaging in a customer-oriented selling approach. Specifically, by utilizing a sample of 345 business-to-business salespeople, this study examines the relationships between moral judgment, customer-oriented selling, and outcome and behavior based performance. Results, managerial implications, and opportunities for future research are provided. (shrink)

The propensity interpretation of fitness (PIF) is commonly taken to be subject to a set of simple counterexamples. We argue that three of the most important of these are not counterexamples to the PIF itself, but only to the traditional mathematical model of this propensity: fitness as expected number of offspring. They fail to demonstrate that a new mathematical model of the PIF could not succeed where this older model fails. We then propose a new formalization of the PIF that (...) avoids these (and other) counterexamples. By producing a counterexample-free model of the PIF, we call into question one of the primary motivations for adopting the statisticalist interpretation of fitness. In addition, this new model has the benefit of being more closely allied with contemporary mathematical biology than the traditional model of the PIF. (shrink)

-/- For all that digital methods—including network visualization, text analysis, and others—have begun to show extensive promise in philosophical contexts, a tension remains between two uses of those tools that have often been taken to be incompatible, or at least to engage in a kind of trade-off: the discovery of new hypotheses and the testing of already-formulated positions. This paper presents this basic distinction, then explores ways to resolve this tension with the help of two interdisciplinary case studies, taken from (...) preregistration in contemporary science and the debate over whig history in the history of science. These case studies, the paper argues, refocus our attention from a mutually exclusive testing/discovery binary to the relationship between our background data or philosophical views and the empirical generalizations that we might draw from the data. Finally, it develops a set of three challenges for philosophers and corresponding avenues for future work that will, it is hoped, allow us to better justify our use of these methods. (shrink)

This chapter contains sections titled: First period (about 1263–74) Second period (about 1274–89) Third period (1290–1308) Final period (1309–16).

This research seeks to better understand how an organization-related employee perception and job attitude may influence organizational members to ethically create customer value. Specifically, it is proposed that high person–organization fit perception, more precisely ethical values person–organization fit perception, can influence business-to-business salesperson commitment to providing superior customer value both directly and indirectly through trust in sales manager, while encouraging ethical salesforce behavior, an important aspect of communicating and delivering customer value. Results from a study of 408 business-to-business salespeople find (...) that ethical values person–organization fit positively influences salesperson commitment to providing superior customer value, as well as trust in manager. Trust in manager directly affects commitment to customer value and mediates the relationship between ethical values person–organization fit and unethical intent. Theoretical and managerial implications are provided, as well as directions for future research. (shrink)

One hotly debated philosophical question in the analysis of evolutionary theory concerns whether or not evolution and the various factors which constitute it may profitably be considered as analogous to “forces” in the traditional, Newtonian sense. Several compelling arguments assert that the force picture is incoherent, due to the peculiar nature of genetic drift. I consider two of those arguments here – that drift lacks a predictable direction, and that drift is constitutive of evolutionary systems – and show that they (...) both fail to demonstrate that a view of genetic drift as a force is untenable. I go on to diagnose the reasons for the stubborn persistence of this problem, considering two open philosophical issues and offering some preliminary arguments in support of the force metaphor. (shrink)

In various writings Maimonides claims that God’s knowledge encompasses sublunar things, including human affairs, that we are incapable of understanding the nature of this knowledge, and that the term “knowing” is equivocal when said of God and of humans. In the fourteenth century these claims were given widely divergent interpretations. According to Levi ben Gershom (Gersonides, 1288–1344), Maimonides was compelled by religious considerations to maintain that God knows sublunar particulars in all their particularity, and to adopt a position that was (...) diametrically opposed to the Aristotelian one. By contrast, Moses of Narbonne (Narboni, d.1362) found Maimonides’ views on divine knowledge to be identical with those of the “ancient philosophers,” that is to say, the Peripatetics, as presented by Averroes. Whether ultimately convincing or not, Narboni’s Averroist interpretation forces the reader to admit that Maimonides shares a great deal more in common with Averroes on this topic than is often thought. By examining briefly the view of Maimonides and Averroes on these matters I hope to make Narboni’s interpretation appear less far-fetched. (shrink)

The poem of Parmenides is the earliest philosophic text which is preserved with sufficient completeness and continuity to permit us to follow a sustained line of argument. It is surely one of the most interesting arguments in the history of philosophy, and we are lucky to have this early text, perhaps a whole century older than the first dialogues of Plato. But the price we must pay for our good fortune is to face up to a vipers' nest of problems, (...) concerning details of the text and the archaic language but also concerning major questions of philosophic interpretation. These problems are so fundamental that, unless we solve them correctly, we cannot even be clear as to what Parmenides is arguing for, or why. And they are so knotted that we can scarcely unravel a single problem without finding the whole nest on our hands. (shrink)

The idea of ‘reversion’ or ‘atavism’ has a peculiar history. For many authors in the latenineteenth and early-twentieth centuries – including Darwin, Galton, Pearson, Weismann, and Spencer, among others – reversion was one of the central phenomena which a theory of heredity ought to explain. By only a few decades later, however, Fisher and others could look back upon reversion as a historical curiosity, a non-problem, or even an impediment to clear theorizing. I explore various reasons that reversion might have (...) appeared to be a central problem for this first group of figures, focusing on their commitment to a variety of conceptual features of evolutionary theory; discuss why reversion might have then ceased to be an interesting phenomenon; and, finally, close with some more general thoughts about the death of scientific problems. (shrink)

The crito takes no stand on the question of whether violating the law is ever morally justified, despite modern attempts to derive a civil disobedience doctrine from it. The argument is largely ad hoc and ad hominem and resistant to generalization as political theory. The central claim is that socrates' escape would be unjust because escape would be an act whose maxim is incompatible with the principle of effective legality. A new construal of the crito's argument is offered and several (...) problems with the argument are discussed. (shrink)

There is a widespread assumption that the universe in general, and life in particular, is 'getting more complex with time'. This book brings together a wide range of experts in science, philosophy and theology and unveils their joint effort in exploring this idea. They confront essential problems behind the theory of complexity and the role of life within it: what is complexity? When does it increase, and why? Is the universe evolving towards states of ever greater complexity and diversity? If (...) so, what is the source of this universal enrichment? This book addresses those difficult questions, and offers a unique cross-disciplinary perspective on some of the most profound issues at the heart of science and philosophy. Readers will gain insights in complexity that reach deep into key areas of physics, biology, complexity science, philosophy and religion. (shrink)

Fitness is a central theoretical concept in evolutionary theory. Despite its importance, much debate has occurred over how to conceptualize and formalize fitness. One point of debate concerns the roles of organismic and trait fitness. In a recent addition to this debate, Elliott Sober argues that trait fitness is the central fitness concept, and that organismic fitness is of little value. In this paper, by contrast, we argue that it is organismic fitness that lies at the bases of both the (...) conceptual role of fitness, as well as its role as a measure of evolutionary dynamics. (shrink)

Rev. and expanded ed. of: How to build a habitable planet / Wallace S. Broecker. 1985.